Dr. Lakshmi Narayanan Lakshmanan

Research Topic

Mitochondrial DNA Deletion Mutagenesis

Education

2014 PhD Chemical Engineering, NUS, Singapore

2008 M.Tech. Medical Biotechnology, IIT Madras, India

2006 B.Tech. Industrial Biotechnology, MSEC Sivakasi, India

Experience

November 2014 - January 2017 Postdoctoral Fellow, ETH Zurich

April - October 2014 Research Assistant, Yale-NUS Singapore

August 2012 - January 2014 Academic Visitor, ETH Zurich

Presentations

LN. Lakshmanan, Z. Yee, J. Gruber, B. Halliwell and R.Gunawan, Deletion mutagenesis of mitochondrial DNA. In Cell Fate Diversity in Aging, Dubrovnik, Croatia, 25-28 September 2016. (poster)
LN. Lakshmanan and R. Gunawan, Thermodynamics Based Model Analysis of Deletion Mutagenesis in Mitochondrial DNA, In the 14^th AIChE Annual Meeting, Atlanta, GA, November 16 – November 21, 2014. (talk)
LN. Lakshmanan, J. Gruber, and R. Gunawan, Mitochondrial DNA Deletion Mutagenesis in Aging. In International Conference of Systems Biology, Toronto, Canada, August 2012. (poster)
LN. Lakshmanan, J. Gruber, B. Halliwell and R. Gunawan, Role of Direct Repeats and DNA Misalignments in mtDNA Deletions: Cause or Coincidence? In Gordon Research Conference on Biology of Aging, Ventura, California, USA, February 2012. (poster)
LN. Lakshmanan, J. Gruber, B. Halliwell and R. Gunawan, Mitochondrial DNA Deletions in Aging – Role of DNA Sequence Motifs. In the 12^th International Conference on Systems Biology, Mannheim, Germany, August 28 - September 1, 2011. (poster)
LN. Lakshmanan, S. K. Poovathingal, and R. Gunawan, Modeling of Age-associated Mitochondrial DNA Deletions in Mouse Cardiac Tissue. In the Conference on Stochastic Systems Biology, Monte Verità, Switzerland, July 2011. (poster)
LN. Lakshmanan, S. K. Poovathingal, and R. Gunawan, Mouse cardiac tissue modeling of age-associated deletions in mitochondrial genome. In The 8^th Workshop in Computational System Biology, Zurich, Switzerland, June 2011.
(poster)
LN. Lakshmanan, S. K. Poovathingal, J. Gruber, B. Halliwell and R. Gunawan, Elucidating Mechanisms of Age-dependent Accumulation of Mitochondrial DNA Deletions – An in silico Approach. In Gordon Research Conference on Biology of Aging, Les Diablerets, Switzerland, August 2010. (poster)

Publications

Fong, S., Teo, E., Ng, LF., Chen, CB., Lakshmanan, LN., Tsoi, SY., Moore, PK., Inoue, T., Halliwell, B. and Gruber, J. Energy crisis precedes global metabolic failure in a novel Caenorhabditis elegans Alzheimer Disease model. Scientific Reports 6 (2016). external page abstract
Lakshmanan, LN., Gruber, J., Halliwell, B. and Gunawan, R. Are mutagenic non D-loop direct repeat motifs in mitochondrial DNA under a negative selection pressure?. Nucleic Acids Research (2015). external page abstract
Poovathingal, S. K., Gruber, J., Lakshmanan, LN., Halliwell, B. and Gunawan, R. Is mitochondrial DNA turnover slower than commonly assumed? Biogerontology 13, 557-564 (2012) . external page abstract
Lakshmanan, LN., Gruber, J., Halliwell, B. and Gunawan, R. Role of direct repeat and stem-loop motifs in mtDNA deletions: cause or coincidence? PloS one 7, e35271 (2012). external page abstract